Integrated Nanosystem for Diagnosis and Therapy


Contract Number

Active Period
2010-2015 Initial PEN

Washington University in Saint Louis
Texas A&M University
University of California, Santa Barbara
University of Texas, SWMC at Dallas

Web Site

$18 Million ca.

Principal Investigators

Robert J. Gropler, M.D.
Washington University School of Medicine
Department of Radiology
510 S. Kingshighway Blvd.
Campus Box 8225 
St. Louis, MO 63110
phone: 314-747-3877
fax: 314-747-3882

Steven L. Brody, M.D.
Washington University School of Medicine
Department of Internal Medicine
660 S. Euclid Avenue
Campus Box 8052 
St. Louis, MO 63110
phone: 314-362-8969
fax: 314-362-8987

Karen L. Wooley, Ph.D.
W. T. Doherty-Welch Professor
Texas A&M University
Department of Chemistry
P.O. Box 30012
College Station, TX 77842-3012
phone: 979-845-4077
fax: 979-862-1137


This PEN will produce integrated nanosystems for the diagnosis and treatment of pulmonary and cardiovascular diseases. The nanomaterials are tailored with specific sizes, shapes and compositions, identified from years of developmental work experience, to provide for enhanced imaging and treatment of lung infectious diseases, acute lung injury, and atherosclerosis. A balance of fundamental and translational research studies and skills development activities are proposed through collaborative interactions among a diverse team of investigators working on four Projects, two Developmental Projects and three Cores, as outlined here and detailed throughout this proposal.

Specific aims for this project include:

Project 1 Aims:

Project 2 Aims:

Project 3 Aims:

Project 4 Aims:

Developmental Project 1 Aims:

Developmental Project 2 Aims:

Nanomaterials Production Core Aims:

Skills Development Core Aims:

Administrative Core Aims:

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